Tested pH balance in dogs. During study he put them into an acidic state to understand homeostasis. He determined that the pH of the blood will be maintained in the short run, but at the expense of an alkali deficit. To maintain long term homeostasis, the body needs to be alkaline.
Consistently healthy nutrition must contain a greater weight of bases (alkaline) than acids.
The prime cause of cellular degeneration is the replacement of the respiration of oxygen in normal body cells by an acidic environment.
“Manual of Physiological & Pathological Chemistry”
Intracellular as well as extracellular chemical reactions influence the pH.
To maintain proper body pH balance, the diet needs to be more alkaline to insure proper levels of oxygen maintain proper health.
The ALKALINE diet provides your pet with the proper pH Balance to oxygenate the blood, which reduces anaerobic activity and cellular degeneration ( aging ).
Summary: The recognition of metabolic factors that influence urinary pH, and uric acid metabolism and excretion, will provide novel insights into the pathogenesis of uric acid stones, and open the way for new therapeutic strategies.
Summary: application of the experimentally determined values for Atot Ka, and net protein charge of canine plasma should improve understanding of the mechanism for complex acid-base disturbances in critically ill dogs.
Summary: pH declined during growth with intracellular acidosis being evident in tumors >350mm3. Whereas lactic acid formation greatly contributed to this decline in small and medium-sized tumors, adenosine triphosphate (ATP) hydrolysis and slowing down of the activities of pumps involved in cellular pH regulation seem to be major factors responsible for intracellular acidification in bulky tumors relatively constant. This coincided with intracellular alkalosis or neutrality and stable adenylate ratios. On average, median pO2 values <10 mmHg coincided with intracellular acidosis, ATP depletion, a drop in energy charge and rising Pi levels.
Summary: Alkaline diets result in a more alkaline urine pH and may result in reduced calcium in the urine. Alkaline diets may benefit bone health, reduce muscle wasting, as well as mitigate other chronic diseases such as hypertension and strokes. An alkaline diet may improve many outcomes from cardiovascular health to memory and cognition. An increase in intracellular magnesium, which is required for the function of many enzyme systems. Alkalinity may result in added benefit for some chemotherapeutic agents that require a higher pH.
Summary: We argue that any level of acidosis may be unacceptable from an evolutionarily perspective, and indeed, that a low-grade metabolic alkalosis may be the optimal acid-base state.
Summary: Results suggest that even subtle chronic acidosis could be sufficient to cause appreciable bone loss over time.
Summary: Research makes a compelling case that diet-induced acidosis is a real phenomenon, has significant clinical relevance, may largely be prevented through dietary changes, and should be recognized and treated.
Summary: Although the pH remains normal initially, such patients easily develop acidemia when stressed because of the steepness of the pH vs. SID plot at low [SID+].